First and Senior Author
1.
Schmitt L.T, Schneider A, Posorski J, Lansing F, Jelicic M, Buchholz F and Sürün D. Quantification of evolved DNA-editing enzymes at scale with DEQSeq. Genome Biology – 2023
2.
Sürün D, Schneider A, Mircetic J, Neumann K, Lansing F, Paszkowski-Rogacz M, Hänchen V, Lee-Kirsch MA, Buchholz F. Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors. Genes – 2020
3.
Sürün D, Schwäble J, Tomasovic A, Roy E, Stein S, Kurrle A, Kühn A, von Melchner H and Schnütgen F. High Efficiency Gene Correction in Hematopoietic Cells by Donor-Template-free CRISPR/Cas9 Genome Editing. Molecular Therapy – Nucleic Acids – 2018
4.
Sürün D, von Melchner H and Schnütgen F. CRSPR/Cas9 genome engineering in hematopoietic cells. Drug Discovery Today: Technologies – 2018
Co-Author
5.
Schönberg PY, Munoz-Ovalle A, Paszkowski-Rogacz M, Crespo E, Sürün D, Feldmann A, Buchholz F. A Pooled CRISPR Screen identifies the Ta2 enhancer element as a driver of TRA expression in a subset of mature human T lymphocytes. Frontiers in Immunology – 2025
6.
Tretbar US, Rurik JG, Rustad EH, Sürün D, Köhl U, Olweus J, Buchholz F, Ivics Z, Fricke S, Blache U. Non-viral vectors for chimeric antigen receptor immunotherapy. Nat Rev Methods Prim – 2024
7.
Kronstein-Wiedemann R, Thiel J, Sürün D, Teichert M, Künzel S.R, Zimmermann S, Buchholz F, and Tonn T. Characterization of imBMEP-A – The first inducible immortalized red blood cell progenitor cell line derived from bone marrow CD71-positive cells. Cytotherapy – 2024
8.
Jelicic M, Schmitt L.T, Paszkowski-Rogacz M, Walder A, Schubert N, Hoersten J, Sürün D, Buchholz F. Discovery and characterization of novel Cre-type tyrosine site-specific recombinases for advanced genome engineering. Nucleic acids research – 2023
9.
Brat C, Huynh Phuoc HP, Awad O, Parmar BS, Hellmuth N, Heinicke U, Amr S, Grimmer J, Sürün D, Husnjak K, Carlsson M, Fahrer J, Bauer T, Krieg SC, Manolikakes G, Zacharowski K, Steinhilber D, Münch C, Maier TJ, Roos J. Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome. Cell chemical biology – 2023
10.
Weisser H, Göbel T, Krishnathas GM, Kreiß M, Angioni C, Sürün D, Thomas D, Schmid T, Häfner AK, Kahnt AS. Knock-out of 5-lipoxygenase in overexpressing tumor cells – consequences on gene expression and cellular function. Cancer Gene Therapy – 2023
11.
Sayed S, Sürün D, Mircetic J, Sidorova OA, Buchholz F. Using CRISPR-Cas9 to dissect cancer mutations in cell lines. Methods in Molecular Biology – 2022
12.
Sayed S, Sidorova OA, Hennig A, Augsburg M, Cortes Vesga CP, Abohamya M, Schmitt LT, Sürün D, Stange D, Mircetic J, Buchholz F. Efficient correction of oncogenic KRAS and TP53 mutations through CRISPR base editing. Cancer Research – 2022
https://aacrjournals.org/cancerres/article/82/17/3002/708290/Efficient-Correction-of-Oncogenic-KRAS-and-TP53
13.
Ding L, Theo Schmitt L, Brux M, Sürün D, Augsburg M, Lansing F, Mircetic J, Theis M, Buchholz F. DNA methylation- independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins. Life science alliance – 2022
14.
Kreiß M, Oberlis J. H, Seuter S, Bischoff-Kont I, Sürün D, Thomas D, Göbel T, Schmid T, Rådmark O, Brandes R.P, Fürst R, Häfner A-K, Steinhilber D. Human 5-lipoxygenase regulates transcription by association to euchromatin. Biochemical pharmacology – 2022
15.
Uebbing S, Kreiß M, Scholl F, Häfner AK, Sürün D, Garscha U, Werz O, Basavarajappa D, Samuelsson B, Rådmark O, Suess B, Steinhilber D. Modulation of microRNA processing by 5-lipoxygenase. FASEB J. – 2021
16.
Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ. Sphingosine-1-phosphate induces potent anti-inflammatory effects in vitro and in vivo by sphingosine-1-phosphate receptor 4-mediated suppression of 5-lipoxygenase activity. FASEB J. – 2019
17.
Nguyen TD, Shaid S, Vakhrusheva O, Koschade SE, Klann K, Thölken M, Baker F, Zhang J, Oellerich T, Sürün D, Derlet A, Haberbosch I, Eimer S, Osiewacz HD, Behrends C, Münch C, Dikic I, Brandts CH. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Blood – 2019
18.
Atlante S, Visintin A, Marini E, Savoia M, Sürün D, Maione F, Schnütgen F, FarsettiA, Zeiher AM, Bertinaria M, Giraudo E, Spallotta F, Cencioni C, and Gaetano C. α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis. Cell Death and Disease – 2018
19.
Cencioni C, Spallotta F, Savoia M, Kuenne C, Guenther S, Re A, Wingert S, Rehage M, Sürün D, Siragusa M, Smith JG, Schnütgen F, von Melchner F, Rieger M, Martelli F, Riccio A, Fleming I, Braun T, Zeiher AM, Farsetti A and Gaetano C. A Zeb1 Hdac2 eNOS feedback circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells. Nature Communications – 2018
20.
Spallotta F, Cencioni C, Atlante S, Garella D, Cocco M, Mori M, Mastrocola R, Kuenne C, Guenther S, Nanni S, Azzimato V, Zukunft S, Kornberger A, Sürün D, Schnütgen F, von Melchner H, Di Stilo A, Aragno M, De Blasio M, Ritchie RH, Zaccagnini G , Martelli F, Farsetti A, Fleming I, Braun T, Beiras-Fernandez A , Botta B, Collino M, Bertinaria M, Zeiher AM, Gaetano C. Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from Type2 diabetes patients: rescue by alpha-ketoglutarate and TET-TDG functional reactivation. Circulation Research – 2018
21.
Ball AK, Beilstein K, Wittmann S, Sürün D, Saul MJ, Schnütgen F, Flamand N, Capelo R, Kahnt AS, Frey H, Schaefer L, Marschalek R, Häfner AK, Steinhilber D. Characterization and cellular localization of human 5-lipoxygenase and its protein isoforms 5-LOΔ13, 5-LOΔ4 and 5-LOp12. Biochim Biophys Acta. – 2017
22.
Tomasovic A, Kurrle N, Wempe F, De-Zolt S, Scheibe S, Koli K, Serchinger M, Schnütgen F, Sürün D, Sterner-Kock A, Weissmann N, von Melchner H. Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function. Matrix Biol. – 2017
23.
Mahshid Y, Markoutsa S, Dincbas-Renqvist V, Sürün D, Christensson B, Sander B, Björkholm M, Sorg BL, Rådmark O, Claesson HE. Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes.Prostaglandins Leukot Essent Fatty Acids – 2015
24.
Tomasovic A, Kurrle N, Sürün D, Heidler J, Husnjak K, Poser I, Schnütgen F, Scheibe S, Seimetz M, Jaksch P, Hyman A, Weissmann N, von Melchner H. Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions. J Biol Chem. – 2015
25.
Markoutsa S, Sürün D, Karas M, Hofmann B, Steinhilber D, Sorg BL. Analysis of 5-lipoxygenase phosphorylation on molecular level by MALDI-MS. FEBS J. – 2014